University of Warwick
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The Denby lab is predominately interested in plant disease resistance: how is the plant defence response regulated, and how does the interaction between the plant and the pathogen determine disease outcome? They use ‘omics data and computational/mathematical biology to elucidate important aspects of the defence response and enhanceunderstanding of plant-pathogen interactions. They use Arabidopsis for most research, but are also translating this fundamental work to crops to speed up breeding for disease resistance. They are particularly interested in the power of modelling to elucidate gene regulatory networks and generate novel biological insight. Elucidating the regulatory networks that underlie complex biological processes is challenging, even more so when trying to unravel host –pathogen interactions, but accurate network models will play a vital role in identifying key defence genes and, more importantly, predicting the combination of genes that should be altered to enhance disease resistance. They generate and integrate large-scale genome-wide data sets, and use and design systems biology tools to generate such network models and further understanding of plant defence as well as broader biotic and abiotic stress responses.
You can see Katherine Denby discuss her research in this video on the GARNet YouTube Channel.